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Calculation of combination index for binary mixtures

Source: R/CIcompX.R
CIcompX.Rd

For single mixture data, combination indices for effective doses as well as effects may be calculated. This is an extended version of CIcomp.

Usage

CIcompX(mixProp, modelList, EDvec, EDonly = FALSE)

Arguments

mixProp

a numeric value between 0 and 1 specifying the mixture proportion/ratio.

modelList

a list containing 3 model fits using drm: the mixture model fit first, followed by the 2 pure substance model fits.

EDvec

a numeric vector of effect levels (percentages between 0 and 100).

EDonly

logical. If TRUE, only combination indices for effective doses are calculated.

Value

A list with components Effx, Effy (unless EDonly = TRUE), CAx, CAy (unless EDonly = TRUE), and EDvec.

References

Martin-Betancor, K. and Ritz, C. and Fernandez-Pinas, F. and Leganes, F. and Rodea-Palomares, I. (2015) Defining an additivity framework for mixture research in inducible whole-cell biosensors, Scientific Reports 17200.

See also

CIcomp, plotFACI, mixture

Author

Christian Ritz and Ismael Rodea-Palomares